Glibenclamide lowers blood sugar concentration in both diabetic and nondiabetic individual by sensitizing functioning of pancreatic beta cells to release insulin in the presence of elevated serum glucose levels.

Gliclazide acts by stimulating the beta cells in the pancreas that produce insulin. These Gliclazide causes the beta cells to produce more insulin. This helps to decrease the amount of sugar in the blood of people with type 2 diabetes.

Metformin helps reduce excessively high blood glucose (sugar) levels in type 2 diabetes patients by decreasing glucose production in the liver, decreasing glucose absorption from the intestine, and improving insulin sensitivity by increasing peripheral glucose uptake and utilization. It does not cause low blood sugars except in special, rare circumstances.